2015). These studies, taken with each other, recommend that, Whilst a immediate activation of GPR55 or PPAR?? takes place, PEA can create its anti?inflammatory motion while in the intestine also via indirect activation of CB1 and CB2 receptors, almost certainly as a consequence of the ability of this compound to potentiate the action of endocannabi

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Of Take note is always that, as a result of PEA’s high lipophilicity, micronized or extremely-micronized formulations are believed for being more simply absorbable, with a lot more favorable pharmacokinetics and larger efficacy. Despite the fact that There is certainly some proof supporting this concept, there continues to be no evidence on the s